Grégory Giannone

Biography

 Grégory Giannone explores the spatiotemporal and mechanical mechanisms driving the dynamics of structures and proteins regulating cell motility. Grégory Giannone started as a CNRS researcher in 2005 in the group of Daniel Choquet. To step towards higher spatial and temporal resolution, from the micron-scale coordination of sub-cellular structures to the nanometer-scale coordination of proteins, he developed projects based on super-resolution imaging and innovative single protein tracking methods. He created a new method of super-resolution imaging allowing for the first time to reveal the dynamics of endogenous proteins at ultra-high density. Using single protein tracking to study synaptogenic adhesion proteins in neurons, he demonstrated that, like integrins, Neuroligin is a ligand-activated adhesion molecule and that its tyrosine phosphorylation controls the formation of inhibitory and excitatory synapses.

Research Interest

 Neurology