Dupont Nathalie

Biography

After obtaining an engineering degree in Chemistry of Materials and a DEA in Materials Science at the Pierre and Marie Curie Paris 6 University, Nathalie Dupont continued her PhD in the laboratory of Cristallochimie du Solide in Paris.  Paris 6 University under the direction of Professor Ariel de Kozak. In July 1999, she obtained her Ph.D. with the jury's written congratulations on the highlighting and study of structure-property relationships in copper (II) complex fluorides. To the In the beginning of 1999, she joined Paris 13 University by obtaining a position as a research professor in the Physical Measurements department of the IUT Saint Denis. After a few years in the Photocatalysis team at LIMHP (UPR CNRS) to work on the development and optimization of a heterogeneous photocatalyst degradation reactor for volatile organic pollutants, Nathalie Dupont joined the laboratory in 2005. has now become the CSPBAT to focus first on structural themes and crystallographic analysis of small molecules, then on in silico modeling of the systems studied. In January 2012, Nathalie Dupont obtained her habilitation to lead research. His area of ​​expertise includes structural analysis by X-ray diffraction,

Research Interest

Highlighting structural relationships - weak links - properties.  Structural study and in silico modeling of supramolecular complexes with pollutants of environmental water. This new subject of research, developed in direct link with the members of the SBMB team by extension of the project ANR REMANTAS, is the subject of the thesis of Shivalika Tanwar under the direction of Nathalie Dupont which began in March 2015. - Computer aided development of peptidomimetics of β and γ elbows This research topic, in collaboration with Dr. Joelle PERARD (CR HDR) of UMR 8638 COMETE of Paris Descartes University, was initiated within the framework of ANR FERRIMAGE. It initially focused on the synthesis of peptidomimetics by  the Paris Descartes team after the in-silico optimization of their skeleton by the Paris 13 team. The initially envisaged diagnostic application focused on the design of inhibitors of certain integrins involved in angiogenesis. However, β and γ elbows are part of the secondary structure of proteins. They participate in the stability of the tertiary structure and are very often involved in intermolecular recognition (peptide / receptor, hormone / receptor, antigen / antibody, enzyme / substrate). A new application involving their incorporation into antimicrobial peptides is currently being considered. - Structural and in silico study of supramolecular complexes involving substituted calixarenes. This project, whose structural study by X-ray diffraction in collaboration with Dr. AWColeman (DR CNRS) of the University of Lyon 1, has given rise to many joint publications is the subject of new developments from a different angle. Indeed, because of the disorder existing in certain crystallographic structures, many unknowns remain on the supramolecular organization of certain studied complexes. In collaboration with Dr. Nohad Gresh of the Laboratory of Theoretical Chemistry, UMR 7616, University Paris 6, the application of the SIBFA polarizable force field to the structure of these complexes should allow to complete their description. In parallel with these research themes, Carole Barbey and Nathalie Dupont provide on-site Bobigny's routine X-ray diffraction analysis of compounds derived from organic synthesis in collaboration with  foreign laboratories (notably Algeria).