Dr. Alexander Ishchenko

Biography

  DNA Repair Group leader   Major publications of Dr ISHCHENKO group Talhaoui I., Lebedeva NA., Zarkovic G., Saint-Pierre C., Kutuzov M.M., Sukhanova M.V., Matkarimov B.T., Gasparutto D., Saparbaev M.K., Lavrik O.I. and Ishchenko A.A. “ Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments”. (under revision) Grin I., and Ishchenko A.A. "An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation”. Nucleic Acids Res., 2016, http://dx.doi.org/10.1093/nar/gkw059 Mazouzi, A., Vigouroux, A., Aikeshev, B., Brooks, P.J., SAPARBAEV, M., Morera, S. and A.A. ISHCHENKO (2013) Insight into mechanisms of 3’-5’ exonuclease activity and removal of bulky 8,5’-cyclopurine adducts by AP endonucleases. Proc. Natl. Acad. Sci. U.S.A. 110(33):E3071-3080. Morera, S., Grin, I., Vigouroux, A., Couve, S., Henriot, V., SAPARBAEV, M. and ISHCHENKO, A.A. (2012) Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil (5hmU)-containing DNA. Nucleic Acids Res., 40(19), 9917-9926. Zlatanou, A., Despras, E., Braz-Petta, T., Boubakour-Azzouz, I., Pouvelle, C., Stewart, G.S., Nakajima, S., Yasui, A., ISHCHENKO*, A.A. and Kannouche*, P.L. (2011) The hMsh2-hMsh6 complex acts in concert with mono-ubiquitinated PCNA and Pol eta in response to oxidative DNA damage in human cells. Mol. Cell, 43, 649-662. Gelin A., Redrejo-Rodríguez M., Laval J., Fedorova O.S., Saparbaev M., Ishchenko A.A. Genetic and Biochemical Characterization of Human AP Endonuclease 1 Mutants Deficient in Nucleotide Incision Repair Activity. PloS One, 2010, 5, e12241. Timofeyeva N.A., Koval V.V., Knorre D.G., Zharkov D.O., Saparbaev M.K., Ishchenko A.A.*, Fedorova O.S.* Conformational Dynamics of Human AP Endonuclease in Base Excision and Nucleotide Incision Repair Pathways // J. Biomol. Struct. Dyn., 2009, 26, 637-652. Daviet S., Couve-Privat S., Gros L., Shinozuka K., Ide H., Saparbaev M. and Ishchenko A.A. Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway // DNA Repair(Amst), 2007, 6, 8-18.  

Research Interest

 DNA Repair