Prof. Eric Solary

Biography

  Group leader:From haematopoietic stem cell to myelomonocytic differentiation   From haematopoietic stem cell to myelomonocytic differentiation group Haematopoietic stem cells (HSCs) in the bone marrow give rise to all lineages of blood cells in a carefully controlled equilibrium. An expansion of the myelomonocytic lineage is associated with inflammation and ageing. A clonal expansion can also be observed in response to some genetic and epigenetic alterations of stem or progenitor cells. Chemo/cytokines and the bone marrow niche environment affect HSC genomic stability, lineage commitment, and cellular differentiation. The group explores the molecular mechanisms that drive myelomonocytic expansion in response to acute or chronic stresses, either inflammatory or genotoxic, and in the context of clonal myelomonocytic leukaemia. We explore the role of three receptors, CSF1-R, CXCR4, and MPL in HSC lineage commitment in steady-state and stress conditions. We also analyse the signalling pathways involved in terminal monocytic differentiation and polarisation. Finally, we dissect the pathogenesis of chronic and acute myelomonocytic leukaemias, using primary cells and various in vitro / in vivo models.  

Research Interest

Onco-haematology