Prof. Hana Raslova
Group leader
From haematopoietic stem cell to megakaryocyte
Gustaveroussy
France
Biography
Prof. Hana Raslova Group leader:From haematopoietic stem cell to megakaryocyte This group belongs to the UMR 1170 “Normal and pathological haematopoiesis” The megakaryocyte differentiation (MK-poiesis) providing platelet production involves two almost unique biological mechanisms in a model of cell differentiation: a polyploidisation through a process called endomitosis and production of mature cells (platelets) in a dynamic mechanism of cytoplasm fragmentation of platelet precursors, megakaryocytes (MKs). Many hereditary or malignant diseases affect MK-poiesis and lead either to thrombocytopenia or to thrombocytosis. These pathologies affect either: signalling pathways, particularly TPO/MPL/JAK2 axis or transcription factors such as GATA1 and RUNX1 grouped into multiprotein complex transcriptional repressors or activators depending on the stage of differentiation, their effectors, and small GTPases.
Research Interest
Onco-haematology
