Bruno Klaholz

Biography

 The research of his team focuses on the study of complexes involved in the regulation of gene expression, particularly at the level of transcription and translation. The research axis on transcription focuses on the function of chromatin remodelling complexes and on nuclear receptors which represent important therapeutic targets. The research axis on translation concerns the mechanism of protein biosynthesis catalyzed by the bacterial and eukaryotic ribosomes. With a strong background in crystallography and cryo electron microscopy acquired during his PhD and then during his postdoc, his group group aims at analyzing various structural and functional states of these large macromolecular complexes by using an integrated structural biology approach to obtain insights into the mechanisms of gene regulation which provide the molecular basis for the development of new drugs.

Research Interest

 The research axis on translation concerns the mechanism of protein biosynthesis catalyzed by the bacterial and eukaryotic ribosomes.