Institut de Génétique et de Biologie Moléculaire et Cellulaire
Dino Moras has completed his Graduation in Chemistry at the University of Strasbourg. While pursuing Post-doc with M G Rossmann, he has contributed to the concept of nucleotide binding domain known as the 'Rossmann fold'. His main scientific contributions are in structural biology, related to the expression of the genetic information: translation of the genetic code by aminoacyl-tRNA synthetases: discovery of the partition of aaRS in two classes and first crystal structure of a class II tRNA-aaRS complex and transcription regulation by Nuclear Receptors: the first crystal structures of the ligand binding domains of two NRs (RXR and RAR) in their apo and liganded form respectively. Presently, his focus is on the molecular mechanisms of regulation using integrative structural biology approaches.
his focus is on the molecular mechanisms of regulation using integrative structural biology approaches.
Allosteric control of transcription regulation by nuclear receptors: An integrative structural biology approach