Ben Shen
Co-chair
medicinal chemistry
The Scripps Research University
France
Biography
Co-chair,Professor,Director, The Natural Products Library Initiative at TSRI-Department of medicinal Chemistry ,Ph.D., Organic Chemistry and Biochemistry, Oregon State University, Corvallis,2011-, Director, The Natural Products Library Initiative at TSRI, TSRI, Jupiter, FL,2017-, Professor and Co-Chair, Department of Chemistry, TSRI, Jupiter, FL,2017-, Professor, Department of Molecular Medicine, TSRI, Jupiter, FL.2011, Fellow, American Association for the Advancement of Science 2015, Promega Biotechnology Research Award, American Society for Microbiology 2002-16, Member, Editorial Board of J. Ind. Microbiol. Biotechnol. 2003-, Member, Editorial Advisory Board of J. Nat. Prod. 2005-, Member, Editorial Board of Curr. Bioactive Compds. 2005-, Member, Advisory Board of Mol. BioSyst. 2006-, Member, Editorial Board of Recent Patents on Anticancer Drug Discovery 2007-, Associate Editor, Acta Microbiologica Sinica 2009-, Member, Editorial Board of J. Antibiot. 2011, Guest Co-Editor, J. Antibiot. January issue in memory of C. Richard Hutchinson 2012, Guest Co-Editor, Curr. Opinion Chem. Biol. April issue on Biocatalysis and Biotransformation 2017-, Editor, J. Ind. Microbiol. Biotechnol.
Research Interest
Natural Product Biosynthesis, Engineering, and Drug Discovery.How can we manipulate nature's biosynthetic machinery for the discovery and development of new drugs.
Publications
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232. Rudolf, J. D.; Chang, C.-Y.; Ma, M.; Shen, B. (2017) Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Nat. Prod. Rep. 34:1141-1172.
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233. Annaval, T.; Rudolf, J. D.; Chang, C.-Y.; Lohman, J. R.; Kim, Y.; Bigelow, L.; Jedrzejczak, R.; Babnigg, G.; Joachimiak, A.; Phillips, G. N. Jr.; Shen, B. (2017) Crystal structure of the thioesterase SgcE10 supporting common polyene intermediates in 9- and 10-membered enediyne core biosynthesis. ACS Omega 2:5159-5169.
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234. Yang, D.; Hindra, Dong, L.-B.; Crnovcic, I.; Shen, B. (2018) Engineered production and evaluation of 6′-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin. J. Antibiot. 71:(DOI:10.1038/ja.2017.93).
