Dr. Julius Rebek Jr

Biography

Dr.Julius had  Ph.D., Organic Chemistry, Massachusetts Institute of Technology.Positions: University of California, Los Angeles .His professional series has Assistant Professor, 1970-1976  University of Pittsburgh Associate Professor, 1976-1979 Professor, 1980-1989  Massachusetts Institute of Technology, Cambridge, MA Professor, 1989-1991 Camille Dreyfus Professor of Chemistry, 1991-1996  The Scripps Research Institute, La Jolla, CA Director, The Skaggs Institute for Chemical Biology and Professor of Chemistry, 1996- Fudan University, Shanghai, China, 2013-2016 Professor of Chemistry, Thousand Talents Program.awards Evans Award, Ohio State University, 2006 Univ. of Oregon Creativity Award in Chemistry, Dance and Music, 2007 Tau-Shue Chou Award, Academica Sinica, 2008 A. von Humboldt Senior Scientist Award, Germany, 2009 Fellow, Royal Society of Chemistry, 2009 Israeli Chemical Society, Honorary Member, 2009 Honorary Doctorate, University of Bonn, 2010 Prelog Medal, ETH Zurich, 2012.editorials Bioorganic and Medicinal Chemistry Letters; Bioorganic and Medicinal Chemistry; Journal of the Chemical Society Perkin Transactions; Chemistry and Biology; Journal of Organic Chemistry; Current Opinion in Chemistry Biology; Progress in Physical Organic Chemistry; Journal of Supramolecular Chemistry. Honorary Doctorate, University Jaume I, Castellon, Spain, 2015 Nichols Medal, ACS New York Section, 2011 .

Research Interest

 Dr. is mainly focused on molecular recognition and catalysis have developed a series of synthetic receptors for small biorelevant molecular targets. These systems are container molecules, deep cavitands, that more-or-less surround the targets and present them with functional groups. This arrangement allows isolation and direct observation of reactive intermediates and catalysis of reactions with large rate enhancements. Molecular self-assembly and encapsulation introduced a series of molecular capsules which self-assemble in the presence of appropriate guest species. These have been prepared in a variety of shapes and sizes, from those appropriate for encapsulation of methane to those capable of encapsulating transition states of cycloaddition reactions. The capsules reveal the behavior of molecules in very small spaces and channel their reactions along previously unknown pathways. The capsules and cavitands represent the leading edge of techniques in physical organic chemistry and provide new sequestering agents for actinide ions. Sensors and antidotes for chemical warfare agents have devised a means by which a large number of nerve agents are rapidly detected and detoxified. The tactic involves combining a fluorescent dye with a reactive nucleophile such as an oxime. Reaction with a nerve agent is followed by a rapid intramolecular cyclization that creates a new fluorophore and destroys the agent. Current research revolves around the selective recognition of agents and their destruction in a catalytic manner. Protein surface mimetics have synthesized small molecule scaffolds that present amino acid side chains that mimic arrangements found in protein alpha helices and beta strands. We have prepared some structures that act as agonists for neuropeptide receptors and others that target proteins involved in innate immunity. Current research involves the design of structures that will interfere with the inflammation cascade that leads to sepsis.