Dr.james C. Paulson

Biography

 Dr.James professional experience Dept. of Biochemistry, Duke University, Postdoctoral Fellow 1974-1978; Dept. of Biol. Chem., Univ. California Los Angeles, Assistant Professor 1978-1981, Associate Professor 1981-1985, Professor and Vice Chair 1985-1990; Cytel Corporation, V.P. Research Development and Board of Directors 1990-1996, Chief Scientific Officer and General Manager and Board of Directors 1996-1999; The Scripps Research Institute, Professor, Depts. of Chemical Physiology and Molecular Biology 1999-2012, Chairman and Professor, Department of Cell and Molecular Biology 2013-2014, Acting President & CEO 2014-2015, Cecil H. and Ida Green Professor and Chairman 2015-2017. Cecil H. and Ida Green Professor and Co-Chair 2017 to present. the awards he got United States EPA Green Chemistry Challenge Award, 2000; Barnett Lecture, 2008; Bijvoet Medal, 2008; Karl Meyer Award, 2009; Melville L. Wolfrom Award, 2016; American Association for the Advancement of Science (AAAS) Fellow 2016. He works as faculty, professor, advisory borad memeber in the scripps university and department of immunology and medicine.

Research Interest

Dr. James mainly aims in  Carbohydrate Binding Proteins in Regulation Of Immune Function .Carbohydrate binding proteins are increasingly recognized to mediate key aspects of cell trafficking and cell signaling in the immune system. At least three families of carbohydrate binding proteins are known to mediate cellular communication among leukocytes. The siglec family now has thirteen members which are expressed on the surface of various white blood cells (e.g. B cells, NK cells, eosinophils, monocytes etc.), and all recognize sialic acid (NeuAc) containing carbohydrate ligands. The best understood for its function is CD22 (siglec-2), which is known to be a negative regulator of B cell receptor signaling. The carbohydrate ligand of CD22 is the sequence  NeuAca2,6Gal on N-linked oligosaccharides of glycoproteins. It is required for normal CD22 function since its absence in mutant mice results in marked immuno-suppression in response to vaccination. Dr.James has his main goal  to elucidate the roles of siglec receptors in immune function, and to define biochemical basis for how the interaction with their carbohydrate ligands modulate their function.