Dr.peter K. Vogt

Biography

  Ph.D., Biology, University of Tübingen, Germany. B.S., University of Würzburg, Germany. His professional series has Ph.D. student, Max Planck Institute, Tübingen, Germany, 1955 - 1959. Ph.D. degree from University of Tübingen, Germany, 1959.Postdoctoral associate, University of California, Berkeley, Virus Laboratory, 1959 – 1962. Assistant and Associate Professor of Pathology, University of Colorado School of Medicine, Denver, Professor of Microbiology, University of Washington School of Medicine, Seattle, 1967 – 1971 Hastings Distinguished Professor of Microbiology and Chairman, Dept. of Microbiology, USC School of Medicine, Los Angeles, 1971 – 1993 Professor, The Scripps Research Institute, La Jolla, since 1993. He has won many awards, lots of publications and is the one ith editorial magazines.

Research Interest

All work is directed at a basic understanding of genetic and epigenetic mechanisms that induce oncogenic transformation of cells. With this information, we conduct screens for small molecules that intervene with the activity of newly identified cancer targets. Our current research focuses on three families of cancer targets: protein and lipid kinases, transcriptional regulators and non-coding, antisense RNA. Among the kinases, phosphatidylinositol 3-kinase (PI3K) has emerged as an important cancer target, because it is frequently mutated in cancer and because most cancers show increased PI3K activity (1). We have characterized the cancer-specific mutations in PI3K (2-5) and continue to explore basic signaling mechanisms that involve this kinase. We are also engaged in the identification and testing of novel specific inhibitors that interfere with oncogenic PI3K.