Joel Gottesfeld
Professor
Molecular Medicine
The Scripps Research University
France
Biography
Professor, Department of Chemistry,Faculty, Graduate Program,Ph.D., Biochemistry, California Institute of Technology, Editorial Board: Associate Editor, Journal of Biological Chemistry.
Research Interest
our studies point to new therapeutic opportunities for the triplet repeat diseases.
Publications
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Thomas, E.A., Coppola, G., Desplats, P.A., Tang, B., Soragni, E., Burnett, R., Gao, F., Fitzgerald, K.M., Borok, J.F., Herman, D., Geschwind, D.H. and J.M. Gottesfeld. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc. Natl. Acad. Sci. USA,105:15564-9, 2008; PMC2563081.
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Herman, D., K. Jenssen, R. Burnett, E. Soragni, S. Perlman and J.M. Gottesfeld. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nature Chem. Biol., 2: 551-558, 2006; PMID:16921367,
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Burnett, R., C. Melander, J.W. Puckett, L.S. Son, R.D. Wells, P.B. Dervan and J.M. Gottesfeld. DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA-TTC repeats in Friedreich's ataxia. Proc. Natl. Acad. Sci. USA, 103:11497-502, 2006; PMC1544198.
