Karl Barry Sharpless
Professor
Chemistry
The Scripps Research University
France
Biography
Ph.D., Chemistry, Stanford University,professor and researcher in Scripps. Won many awards and honors like ACS Award for Creative Work in Synthetic Organic Chemistry, 1983; Dr. Paul Janssen Prize for Creativity in Organic Synthesis, 1986; AIC Chemical Pioneers Award, 1988; ETH Prelog Medal, 1988; Scheele Medal, 1991; ACS Arthur C. Cope Award, 1992; Tetrahedron Prize for Creativity in Organic Chemistry, 1993; The King Faisal International Prize for Science, 1995; ACS Roger Adams Award in Organic Chemistry, 1997; Member, National Academy of Sciences, 1985. Nobel Prize in Chemistry, 2001; Chirality Medal, Italian Chemical Society, 2001; Rhone Poulenc Medal, Royal Society of Chemistry, United Kingdom, 2001; Benjamin Franklin Medal in Chemistry, Franklin Institute, Philadelphia, Pennsylvania, 2001; Wolf Prize in Chemistry, Wolf Foundation, Herzlia Bet, Israel, 2001; Nobel Prize in Chemistry (with W. Knowles and R. Noyori), 2002. Editorial Boards: Tetrahedron Publications, Catalysis Technology, Enantiomer, Advanced Synthesis and Catalysis, Chirality, Topics in Stereochemistry, Current Opinion in Drug Discovery and Development, Organic Letters, Synlett.
Research Interest
click chemistry a far-reaching method for drug discovery, chemical biology and materials science.
Publications
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Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. Miyamoto, Y.; Kalisiak, J.; Korthals, K.; Lauwaet, T.; Cheung, D. Y.; Lozano, R.; Cobo, E. R.; Upcroft, P.; Upcroft, J. A.; Berg, D. E.; Gillin, F. D.; Fokin, V. V.; Sharpless, K. B.; Eckmann, L. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 17564.
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Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. Dong, J.; Krasnova, L.; Finn, M.G.; Sharpless K. B. Angew. Chem. Int. Ed. Accepted.
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A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry. Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB. Angew Chem Int Ed Engl. 2016 Oct 10. doi: 10.1002/anie.201608807.
