Luke Lairson
Professor
Medicinal Chemistry
The Scripps Research University
France
Biography
Department of Molecular Medicine-Faculty, Graduate Program, researcher, professor in Scripps university,Ph.D., Chemistry , University of British Columbia,Principal Investigator, Genomics Institute of the Novartis Research Foundation,Professor (Research-Track), Department of Chemistry, The Scripps Research Institute, Principal Investigator, California Institute for Biomedical Research .
Research Interest
Our research efforts ultimately result in chemistry-based discovery of novel biological mechanisms and the direct enablement of new drug discovery programs.
Publications
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Bollong M.J., Yun H., Sherwood L., Woods A.K., Lairson L.L.*, Schultz P.G.* (2015) A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chemical Biology. 10: 2193-2198. * co-corresponding author
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Mullarky, E., Lucki, N., Beheshti Zavareh, R., Anglin, J., Gomes, A.P., Nicolay, N.G., Wong, J.C.Y, Christen, S., Takahashi, H., Singh, P.K., Blenisa, J., Warren, D., Fend, S.M., Asarai, J.M., DeNicola, G.M., Lyssiotis, C.A., Lairson, L.L.* and Cantley, L.C.* (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Science USA. 113: 1778-83. * co-corresponding author
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Bollong M.J., Yang B., Vergani N., Beyer B.A., Chin E.N., Zambaldo C., Wang D., Chatterjee A.K., Lairson, L.L.*, Schultz P.G.* (2017) Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. Proceedings of the National Academy of Science USA. In Press. * co-corresponding author
