Genetics Experts

Giovanni Marsicano

The Neuroscience Institute at Bordeaux

Giovanni Marsicano


The general goal of our group is to understand the cell type-specific role of the endocannabinoid system (ECS) in brain and neuronal functions. The ECS in the brain is formed by the type-1 cannabinoid receptors (CB1), by their endogenous lipid ligands the endocannabinoids (mainly arachidonoyl-ethanolamine, AEA, and 2-arachidonoyl-glycerol, 2-AG), and by the machinery for synthesis and degradation of endocannabinoids. The major effect of CB1 activation is the decrease of neuronal excitability and the presynaptic reduction of neurotransmitter release. As these receptors are expressed both on GABAergic and glutamatergic terminals, their ability to dampen both inhibitory and excitatory neurotransmission could underlie different and even opposite effects of the ECS on neuronal functions and behaviour. To understand the specific role(s) of CB1 signalling in these two neuronal populations, we developed advanced conditional genetic tools, allowing the deletion of CB1 receptors in specific neuronal populations in mice. Using these tools, we studied the effects of the conditional deletion of CB1 in GABAergic and cortical glutamatergic neurons. During the last years, we obtained results pointing to the novel idea that the ECS exerts different functions, depending of the cell type-specific expression of CB1. In detail, CB1 receptors on cortical glutamatergic neurons mediate the well-known neuroprotective and orexigenic functions of the ECS and account for some classical effects of CB1 agonists. Surprisingly, the abundant expression of CB1 in GABAergic neurons is not involved in ECS-dependent neuroprotection and in classical effects of CB1 agonists, but it mediates so-far unsuspected pro-neophobic and anorectic functions of the ECS. These results provided a new vision of the ECS and allowed the publication of interesting articles. They also constitute the ground for our future projects, in which the polymodal mechanisms of action of the ECS will be further detailed and investigated.

Research Interest

Molecular Mechanisms of Behavioral Adaptation

Global Experts from Gambia

Global Experts in Subject

Share This Profile
Recommended Conferences
  • World Congress on Organ Transplantation and Artificial Organs

    August 24-25, 2018 Tokyo, Japan

  • World Congress on Stem Cell Biology and Biobanking

    September 3-4, 2018 Tokyo, Japan

  • 22nd Global Biotechnology Congress

    September 10-11, 2018 Stockholm, Sweden

  • 11th International Conference on Genomics and Pharmacogenomics September 21-22, 2018 Philadelphia, Pennsylvania, USA

    September 21-22, 2018 Philadelphia, USA

  • 5th International Conference on Human Genetics and Genetic Disorders September 21-22,2018 Philadelphia, Pennsylvania, USA

    September 21-22,2018 Philadelphia, USA

  • 11th International Conference on Genomicsand Pharmacogenomics

    September 21-22, 2018 Philadelphia, USA

  • 5th World Congress on HUMAN GENETICS SEPTEMBER 24-25, 2018 BERLIN, GERMANY

    SEPTEMBER 24-25, 2018 Berlin, Germany

  • 11th Annual Conference on Stem Cell and Regenerative Medicine

    October 15-16, 2018 Helsinki, Finland

  • Next Generation Sequencing and Biostatistics

    Oct 23-24, 2018 Dubai

  • 24th Biotechnology Congress: Research & Innovations

    October 24-25, 2018 Boston, USA

  • 3rd World Biotechnology Congress

    Dec 03-04, 2018 Sao Paulo, Brazil

View more