Tim F. Greten, M.d.
Head, Gastrointestinal Malignancy Section
Thoracic and Gastrointestinal Oncology Branch
Centre of Hepatology, Gastroenterology and Dietetics
Germany
Biography
Dr. Greten is an expert in GI Oncology and tumor immunology. His specific research focus is liver cancer and immunology. He is trying to better understand how tumors in the liver interact with the immune system. Dr. Greten has his received his training in Medical Oncology, Gastroenterology and Hepatology in Germany and has been performing basic and translational research studies in tumor immunology for more than 20 years. He is currently studying novel immune based approaches to treat patients with primary hepatobiliary tumors and patients with tumors of the GI tract metastasizing into the liver.
Research Interest
) Gastrointestinal Cancer 2) Tumor immunology and Immunotherapy 3) Hepatocellular Carcinoma 4) Liver Immunology and Cancer 5) Preclinical and Translational Studies
Publications
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Tremelimumab in Combination with Ablation in Patients with Advanced Hepatocellular Carcinoma. Duffy AG, Ulahannan SV, Makorova-Rusher O, Rahma O, Wedemeyer H, Pratt D, Davis JL, Hughes MS, Heller T, ElGindi M, Uppala A, Korangy F, Kleiner DE, Figg WD, Venzon D, Steinberg SM, Venkatesan AM, Krishnasamy V, Abi-Jaoudeh N, Levy E, Wood BJ, Greten TF. Journal of Hepatology. 2016. [ Journal Article ] A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Krüger C, Manns MP, Greten TF, Korangy F. Gastroenterology. 135: 234-43, 2008. [ Journal Article ] Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma. Kapanadze T, Gamrekelashvili J, Ma C, Chan C, Zhao F, Hewitt S, Zender L, Kapoor V, Felsher DW, Manns MP, Korangy F, Greten TF. J. Hepatol. 59: 1007-13, 2013. [ Journal Article ]
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NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. Nature. 531: 253-7, 2016. [ Journal Article ] Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.. Eggert T, Wolter K, Ji J, Ma C, Yevsa T, Klotz S, Medina-Echeverz J, Longerich T, Forgues M, Reisinger F, Heikenwalder M, Wang XW, Zender L, Greten TF. Cancer Cell. 30: 533-47, 2016. [ Journal Article ]
