Rolf Marschalek
Pharmaceutical Biology
Frankfurt University
Germany
Biography
Prof. Dr. Rolf Marschalek born on 23 December 1960 Place of birth: Heidenheim / Brenz Academic education: University: 1980-1986 Studies of Biology (Diploma) at the University of Erlangen / Nuremberg Doctorate: 1986-1989 University of Erlangen / Nuremberg (degree: summa cum laude); Subject of the dissertation: Organization and expression of tRNA genes in lower eukaryotes. Post-Doc / Scientific Assistant: • 1989-1990 Institute of Biochemistry of the Medical Faculty of the University of Erlangen / Nuremberg (Prof. W. Kersten) 1991 Post-doctoral postdoctoral stay at the Institute of Genetics, Maquarie University Syndney (Australia) Williams) • 1991-1992 Institute for Biochemistry of the Medical Faculty of the University of Erlangen / Nuremberg (Prof. W. Kersten), postdoctoral fellowship of the DFG • 1992-2000 scientific assistant C1 at the Chair of Genetics (Prof. GH Fey) at the University of Erlangen -Nuremberg Habilitation: 1999 (Genetics); Senior scientific assistant C2. 2000 Appointed professor for Molecular Medicine to the University of Hamburg; Call rejection 2000 Appointed to a C3 Professorship for Pharmaceutical Biology at the University of Frankfurt; Call acceptance
Research Interest
Diagnostics, molecular pathomechanisms and therapy of high-risk acute lymphocytic leukemia (ALL) in small children, adolescents and adults (caused by MLL translocations) - Diagnostic, molecular pathomechanisms and therapy of high-risk acute lymphoblastic leukemia (ALL) in infants, children and adults (caused by MLL translocations)
Publications
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Identification of a Cryptic Insertion ins(11;X)(q23;q28q12) Resulting in a KMT2A-FLNA Fusion in a 13-Month-Old Child with Acute Myelomonocytic Leukemia. Lentes J, Thomay K, Schneider DT, Bernbeck B, Reinhardt D, Marschalek R, Meyer C, Schlegelberger B, Göhring G. Cytogenet Genome Res. 2016;150(3-4):281-286.
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Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Ball AK, Beilstein K, Wittmann S, Sürün D, Saul MJ, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber D. Biochim Biophys Acta. 2017 May;1862(5):561-571
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TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation. Saul MJ, Groher F, Hegewald AB, Müller-McNicoll M, Marschalek R, Suess B, Steinhilber D. Prostaglandins Other Lipid Mediat. 2017 Aug 11
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A Case of Acute Myeloid Leukemia with Novel Translocation t(6;11)(p22.2;q23) and Concurrent Insertion ins(11;9)(q23;p21.3p21.3). Malinowska I, Sikorska-Fic B, Romiszewska M, Stefaniak A, Pastwińska A, Górska E, Popko K, Meyer C, Marschalek R, Szczepański T. Adv Exp Med Biol. 2017 Aug 8
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Marschalek R.. Mechanisms of leukemogenesis by MLL fusion proteins. Br J Haematol 152: 141-154
