Haike Antelmann

Biography

Education and Qualification 1988 -1993 Study of “Biopharmacology” at the Ernst-Moritz-Arndt-University of Greifswald 1994 -1998 Ph.D in Microbiology under supervision of Prof. M. Hecker in the Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald 5th March 1998 PhD Graduation in “Microbiology” (Title: Dr. rer. nat.) Title of PhD thesis: „ From a two-dimensional protein index in Bacillus subtilis towards the characterization of novel general stress proteins” 1999-2005 Postdoctoral research in the Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald in the group of Prof. M. Hecker 2006-Sept. 2015 Group leader for "Oxidative Stress physiology in bacteria", Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald 19th Feb 2009 Habilitation as Associate professor in “Microbiology” (Title: Dr. rer. nat. habil.) Title of Habilitation Thesis: „Proteomics of protein secretion mechanisms and regulation of thiol-specific electrophile resistance mechanisms in Bacillus subtilis” Since Okt. 2015 Full professor for Molecular Microbiology, Institute for Biology-Microbiology, Freie University Berlin

Research Interest

My research focus are the molecular mechanisms of oxidative and electrophilic stress responses in Gram-positive bacteria. We investigate the changes in the transcriptome and post-translational thiol-modifications caused by ROS and RES in Gram-positive bacteria in the thiol-redox proteome and the regulatory mechanisms of novel redox-sensing regulators. Most recent research involves the physiology and thiol-modifications caused by bacillithiol and mycothiol in different Gram-positive bacteria. We found that bacillithiol and mycothiol play important roles in redox regulation and protection of essential and conserved proteins against irreversible oxidation by protein S-bacillithiolation and protein S-mycothiolation. Future studies involve the investigation of the physiological roles and impact for virulence mechanisms of these thiol-modifications in pathogenic Gram-positives.