Sigmar Stricker
Biochemistry
Free University of Berlin
Germany
Biography
Scientific background 1993-1998 Study of biology at the Johannes Gutenberg University Mainz, Diploma Thesis "The primary structure of the hemocyanin subunits f, g and h of Haliotis tuberculata" in the lab of Prof. Dr. Jürgen Markl. 1998-2002 PhD student in the lab of Prof. Dr. Stefan Mundlos in Berlin Thesis: Molecular Genetic Analysis of the Cartilage Differentiation in the Skeleton of Vertebrates ", awarded" summa cum laude ". 2002-2004 Postdoctoral fellow in the lab of Prof. Dr. Stefan Mundlos in Berlin 2005-present Project group leader in the lab of Prof. Dr. Stefan Mundlos in Berlin Since 2011 Associated Investigator at the Berlin School of Management for Regenerative Therapies (BSRT). 2010 Faculty Rank ("Habilitation") in Experimental Human Genetics, Charité University Medicine Berlin 2012 Extension of the Habilitation ("Extension of the Teaching Qualification") to Biochemistry; Free University of Berlin 2013 Professor at the Department of Biochemistry, Institute of Chemistry and Biochemistry; Free University of Berlin
Research Interest
special interest is the muscle, the connective tissue and the skeleton. We are also interested in the interaction of these tissue types during development and their alteration in certain diseases. Regenerative processes, Eg after injuries, are to a certain extent a recapitulation of development processes. One goal of our research is therefore to use the fundamental understanding of development in order to better understand regenerative processes and to promote them in the long term
Publications
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Black W, Witte F, Rajab A, Mouthless S, Stricker S. (2009) A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum Mol Genet. 18 (21): 4013-4021.
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Witte F, Bernatik O, Kirchner K, Masek J, meal A, Krejci P, mouthless S, Schambony A, Bryja V, Stricker S. (2010) Negative regulation of Wnt signaling by CK1 phosphorylated Disheveled via Ror2. FASEB J. 24: 2417-2426.
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Witte F, Chan, Economides AN, Mundlos S, Stricker S. (2010) Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Nat Aca Sci. USA 107 (32): 14211-14216.
