Christopher Overall
Proteomics and Systems Biology
Freiburg Institute for Advanced Studies
Germany
Biography
Dr. Overall is a Professor and Tier 1 Canada Research Chair in Metalloproteinase Proteomics and Systems Biology at the University of British Columbia, Center for Blood Research. He completed his undergraduate, Honors Science and Masters degrees at the University of Adelaide, South Australia; his Ph.D. in Biochemistry at the University of Toronto; and what a MRC Centennial Fellow did in his post-doctoral work with Dr Michael Smith's Nobel Laureate, Biotechnology Laboratory. He won the CIHR Institute of Musculoskeletal Health and Arthritis 2002 Researcher of the Year Award, the University of British Columbia. On Sabbatical in 1997-1998 he was a Visiting Scientist at British Biotech Pharmaceuticals, Oxford, UK and in 2004/2008 he was a Visiting Scientist at the Expert Protease Platform, Novartis Pharma, Basel, Switzerland. He is the pioneer of the field of proteomics now termed degradomics, with 6 NatureReviewPapers on this, protease genomics, drug target validation, MMP therapeutics, and substrate discovery. The invention relates to a method and apparatus for the diagnosis of cell carcinogenesis in vitro. From his 2000 study, he was able to demonstrate the role of MMPs in the regulation of extracellular homeostasis. By developing new global approaches for the proteolysis of proteolysis, the biological roles of proteases is complex.
Research Interest
His current research focuses on Systems biology and degradation of proteolysis in cancer and metastasis
Publications
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(MMP25): chemokine and vimentin cleavage enhance cell migration and macrophase phagocytic activities. J Biol Chem , 2012; 287 (16): 13382-13395
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AE Starr, A. Dufour, J. Maier, CM Overall: Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. J Biol Chem , 2012; 287 (8): 5948-5860.
