Leena Bruckner-tuderman
Dermatology
Freiburg Institute for Advanced Studies
Germany
Biography
Leena Kaarina Bruckner-Tuderman is professor and chair of the Department of Dermatology at the University Medical Center, Albert-Ludwigs-University of Freiburg. She studied medicine in Oulu, Finland, and after an experimental dissertation in molecular medicine, continued her postdoctoral work in biochemistry in Piscataway, NJ, USA, and in structural biology in Basel, Switzerland. She has received a doctorate degree from the Swiss National Science Foundation (Habilitation) at the University of Zurich, Switzerland, 1988. From 1990 to 1994 she was a Fellow of the Swiss National Science Foundation. In addition to this, the company has been a member of the German Research Foundation (DFG) and moved to the Münster University, Germany, where she became professor of dermatology and venerology. During this period in Münster she was also a visiting professor at the University of Hong Kong and at Harvard Medical School, Boston. In 2002, she was appointed a professor and chair of dermatology and venereology at the University of Freiburg Institute for Advanced Studies.
Research Interest
Research Focus Molecular genetics and disease mechanisms of skin disorders, biology of basement membranes and the extracellular matrix, epithelial-mesenchymal communication, cell-matrix interactions. Development of cell, gene, and protein-based therapies.
Publications
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D. Kiritsi, Y. He, A. Puck, M. Onder, R. Happle, M. Jonkman, L. Bruckner-Tuderman, C. Has: Revertant mosaicism in a human skin fragility disorder results from slipped mispairing and mitotic recombination. J Clin Invest. 2012; 122 (5): 1742-1746.
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CW Franzke, C. Cobzaru, A. Triantafyllopoulou, S. Loffek, K. Horiuchi, DW Threadgill, T. Kurz, N. van Rooijen, L. Bruckner-Tuderman, CPBlobel: Epidermal ADAM17 EGFR ligand- dependent terminal keratinocyte differentiation. J Exp Med, 2012.
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C. Has, G. Sparta, D. Kiritsi, L. Weibel, A. Moeller, V. Vega-Warner, A. Waters, Y. He, Y. Anikster, P.Esser, BK Straub, I. Hausser, D B, B, B, B, B, Bruckner-Tuderman, G. Laube: Integrin alpha3 mutations with kidney, lung, and skin disease. New Engl J Med, 2012; 366 (16): 1508-1514.