Pascale Romby
molecular biology
Freiburg Institute for Advanced Studies
Germany
Biography
Pascale Romby, born in 1958, is Director of the CNRS Unit "Architecture and Reactivity of RNA" at the Institute of Molecular and Cellular Biology (IBMC) since September 2016. Doctor ès Sciences, Pascale Romby has a CNRS researcher position since 1987, and leads the research team entitled "mRNAs and regulatory RNAs in bacteria". She has contributed to 130 publications in peer-reviewed international journals. She is a member of various editorial committees including RNA Biol, Pathogens and Diseases, Biochemistry, and Virulence. She has received several awards, ie the silver medal of the CNRS in 2016 and the Langevin Prize of the Academy of Sciences in 2010.
Research Interest
P. Romby's team has the general objective to get a global and integrated view of the roles of RNAs in gene regulation and to decipher the intricate link between transcriptional and posttranscriptional regulators in the opportunistic pathogen Staphylococcus aureus . In addition to the above, the present invention relates to a method and apparatus for the detection of mRNAs in a mammalian plant. The team has tested novel translational regulatory mechanisms, mediated either by proteins or non-coding RNAs (sRNAs) in Escherichia coli and Staphylococcus aureus , and the key roles of several regulatory networks involving sRNAs that link stress adaptation, metabolism, and virulence in S. aureus.
Publications
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A, CHOULIER L, MICURA R, KLAHOLZ BP, ROMBY P *, SPRINGER M, MARZI S *. (2013) Escherichia coli ribosomal protein S1 unfolded structured mRNAs on the ribosome for active translation initiation. PLoS Biol . 11 (12): e1001731.
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LIOLIOU E, SHARMA CM, CALDELARI I, HELPER AC, FECHTER P, VANDENESCH F, VOGEL J, ROMBY P (2012) Global regulatory functions of the Staphylococcus aureus endoribonuclease III in gene expression. PLoS Genet . 8 (6): e1002782.
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A search for small noncoding RNAs in Staphylococcus aureus revealed a conserved sequence of motifs for regulation. [Article in German] Kerstin K, Keith K, Nucleic Acids Res . 2009 Nov., 37 (21): 7239-57.
