Stuart Conway
Professor
Organic Chemistry
Freiburg Institute for Advanced Studies
Germany
Biography
Stuart Conway is a Professor of Organic Chemistry at the University of Oxford, and the E. P. Abraham Cephalosporin Fellow in Organic Chemistry at St Hugh's College, Oxford. He studied Chemistry with Medicinal Chemistry at the University of Warwick before undertaking PhD studies with Professor David Jane in the Department of Pharmacology at the University of Bristol. Stuart completed post-doctoral studies with Professor Andrew Holmes FRS at the University of Cambridge working on the synthesis of inositol polyphosphates. In 2003, he was appointed as a Lecturer in Bioorganic Chemistry at the University of St Andrews, in 2008 was appointed as an Associate Professor at Oxford, and in October 2014 he was promoted to Full Professor. Between March and August 2013 Stuart was a Visiting Associate at the California Institute of Technology, hosted by Professor Bob Grubbs and Professor Dianne Newman.
Research Interest
Stuart's research focuses on the development of molecular tools to enable the study of biological systems.Our research interests are at the interface of chemistry and biology and focus on the use of synthetic organic chemistry to enable the study of biological problems. Key areas of activity include the synthesis of inositol-based probes to study intracellular calcium signalling, the synthesis of inositol-based compounds to probe pleckstrin homology domains and the use of photolabile protecting groups to develop light-activated molecular tools.
Publications
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M. N. Stanton-Humphreys, R. D. T. Taylor, C. McDougall, M. L. Hart, C. T. A. Brown, N. J. Emptage, S. J. Conway, Wavelength-orthogonal photolysis of neurotransmitters in vitro. Chem. Commun., 2012, 48, 657-659.
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D. S. Hewings, O. Fedorov, P. Filippakopoulos, S. Martin, S. Picaud, A. Tumber, C. Wells, M. M. Olcina, K. Freeman, A. Gill, A. J. Ritchie, D. W. Sheppard, A. J. Russell, E. M. Hammond, S. Knapp, P. E. Brennan, S. J. Conway, Optimization of 3,5-dimethylisoxazole derivatives as potent BET bromodomain ligands. J. Med. Chem., 2013, 56, 3217-3227.
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C. Cazares-Körner, I. M. Pires, I. D. Swallow, S. C. Grayer, L. O’Connor, M. M. Olcina, M. Christlieb, S. J. Conway, E. M. Hammond, CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A. ACS Chem. Biol., 2013, 8, 1451-1459.