Udo Oppermann
molecular biology
Freiburg Institute for Advanced Studies
Germany
Biography
Udo Oppermann obtained a Diploma in Human Biology in 1990 and PhD in Pharmacology and Toxicology in 1994, both with distinctions from Philipps University Marburg, Germany. He has been a Principal Investigator of the Structural Genomics Consortium (SGC) in the Department of Medical Biochemistry and Biophysics Oxford since its inception in 2003. In 2008 he became Professor of Molecular Biology at NDORMS, and he is now Deputy Director of the Institute of Musculoskeletal Sciences, Botnar Research Center, University of Oxford, as well as a Fellow of St Catherine's College . (SDR, MDR), or oxidative enzymes as as.The present invention relates to a method and apparatus for the determination of the metabolic activity of a mammalian species ketoglutarate-dependent oxygenases.The use of chemical biology to human biology is a major focus of the group and is currently directed to the field of epigenetic mechanisms in stem cell biology, as well as chronic inflammatory and metabolic diseases.
Research Interest
His current research focuses on Understanding the role of histone demethylase LSD1 in mesenchymal stem cell biology and musculoskeletal aging
Publications
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Korczynska M, Le DD, Younger N, Gregori-Puigjané, Tumber A, Krojer T, Velupillai S, Gileadi C, Nowak RP, Iwasa E, Pollock SB, Ortiz Torres I, Oppermann U, Shoichet BK, Fujimori DG. Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25; 59 (4): 1580-98.
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Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul .; 12 (7): 539-45.
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Nowak RP, Tumber A, Johansson C, Che KH, Brennan P, Owen D, Oppermann U. Advances and challenges in understanding histone demethylase biology. Curr Opin Chem Biol 2016 Jun 29, 33: 151-159.
