Günther Schütz

Biography

We study in mice how signaling molecules such as steroid hormones control the activity of genes. With genetic methods we investigate how extra cellular signals control the activity of genes via receptors on the cell surface or in the nucleus. To identify the role of these signal-dependent transcription factors during development and in physiological states we alter the genes in mice by homologous recombination. Since germ line mutations are frequently lethal we use site-specific recombination systems which allow conditional and function-selective mutagenesis. The analysis of these mouse mutants thus leads to important insights in the function of signal-dependent transcription factors. We study in mice how signaling molecules such as steroid hormones control the activity of genes. With genetic methods we investigate how extra cellular signals control the activity of genes via receptors on the cell surface or in the nucleus. To identify the role of these signal-dependent transcription factors during development and in physiological states we alter the genes in mice by homologous recombination. Since germ line mutations are frequently lethal we use site-specific recombination systems which allow conditional and function-selective mutagenesis. The analysis of these mouse mutants thus leads to important insights in the function of signal-dependent transcription factors.

Research Interest

molecular biology