Magnus Von Knebel Doeberitz

Biography

The Clinical Cooperation Unit Applied Tumor Biology is a research collaboration with the Department of Molecular Pathology of Heidelberg University Hospitals. Our interest is focused on fundamental mechanisms that impair the stability of the genetic material and thus promote tumor development. If the chromosomes, which carry the hereditary information (genes) of a cell, are unstable, gene activity can get out of control leading to malignant transformation of the cell. Researchers in our working group are studying such changes using solid tumors and comparing these with the gene activity of healthy cells. If characteristic differences are identified, clinical studies are conducted to test whether these may serve as diagnostic criteria. Moreover, researchers are analyzing the reactions of the immune system in patients treated with new substances deemed suitable for treating cancer. It is our aim to develop vaccines for cancer prevention and treatment on this basis. Our work is concentrated on tumors associated with human papillomavirus (HPV) and hereditary colorectal cancers The Clinical Cooperation Unit Applied Tumor Biology is a research collaboration with the Department of Molecular Pathology of Heidelberg University Hospitals. Our interest is focused on fundamental mechanisms that impair the stability of the genetic material and thus promote tumor development. If the chromosomes, which carry the hereditary information (genes) of a cell, are unstable, gene activity can get out of control leading to malignant transformation of the cell. Researchers in our working group are studying such changes using solid tumors and comparing these with the gene activity of healthy cells. If characteristic differences are identified, clinical studies are conducted to test whether these may serve as diagnostic criteria. Moreover, researchers are analyzing the reactions of the immune system in patients treated with new substances deemed suitable for treating cancer. It is our aim to develop vaccines for cancer prevention and treatment on this basis. Our work is concentrated on tumors associated with human papillomavirus (HPV) and hereditary colorectal cancers

Research Interest

Tumor Biology