Dr. Dan Ehninger
Professor
Center for Neurodegenerative Diseases
German Centre for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen)
Germany
Biography
Dan Ehninger studied medicine in Berlin from 1997 to 2003. From 2001 to 2004, he carried out his medical thesis in the laboratory of Gerd Kempermann at the Max Delbrück Center for Molecular Medicine in Berlin, where he worked on the behavioral regulation of adult hippocampal neurogenesis and adult cell formation in the neocortex. His postdoctoral work (2004 to 2009) with Alcino Silva at University of California - Los Angeles (Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, Psychology and the Brain Research Institute) focused on molecular and cellular mechanisms of cognitive impairments in mouse models of neuropsychiatric disorders. Since 2010, Dan Ehninger is group leader at the DZNE in Bonn.
Research Interest
The group is interested in the neurobiological mechanisms that underlie learning and memory formation under physiological conditions. Additionally, our research efforts focus on pathophysiological mechanisms relevant for cognitive impairments in the context of aging and neuropsychiatric disorders. We use an interdisciplinary research approach based on methods of mouse genetics, behavioral neuroscience, molecular biology and biochemistry, neuroanatomical analyses and neurophysiological studies.
Publications
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SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G. Autophagy 2017, 13: 885-899.
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High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice. Henzel KS, Ryan DP, Schröder S, Weiergräber M, Ehninger D. Sci Rep 2017, 7:3098.
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A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Ryan DP, Henzel KS, Pearson BL, Siwek ME, Papazoglou A, Guo L, Paesler K, Yu M, Müller R, Xie K, Schröder S, Becker L, Garrett L, Hölter SM, Neff F, Rácz I, Rathkolb B, Rozman J, Ehninger G, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Sidiropoulou K, Weiergräber M, Zhou Y, Ehninger D. Mol Psychiatry 2017
