Dr. Daniele Bano
Professor
Center for Neurodegenerative Diseases
German Centre for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen)
Germany
Biography
Dr. Daniele Bano graduated and received his PhD at the University of Padova, Italy. During his PhD programme, he was a visitor student at the University of Konstanz. In 2002, he moved to the laboratory of Prof. Pierluigi Nicotera at the MRC Toxicology Unit, University of Leicester (UK). Then, in 2007 he joined the laboratory of Prof. Michael O. Hengartner at the Institute of Molecular Biology, University of Zurich (Switzerland). Between 2008 and 2009 he was recruited as a Principal Investigator at the MRC Toxicology Unit, University of Leicester (UK). Since 2009, Daniele Bano is Research Group Leader at the German Center for Neurodegenerative Diseases (DZNE), Bonn.
Research Interest
Progressive decline of fitness and health are common aspects of organismal aging. The diminished maintenance of tissue homeostasis increases the susceptibility to chronic diseases that may lead to disability and neurological conditions. Sporadic forms of neurodegenerative disorders undoubtedly rank among the major causes of illness and mortality worldwide, with a higher risk of incidence in elderly people. Due to the limited number of treatments, there is an increased urgency to develop novel long-term effective strategies that help to ameliorate such debilitating disorders. Multiple factors participate in the detrimental cascades that are causally linked to brain pathologies. Despite the substantial progress in this field, several aspects of age-related disease pathogenesis remain elusive. A better understanding of the underlying mechanisms may provide strategies for the prevention and the treatment of pathological conditions.
Publications
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Loss of apoptosis-inducing factor critically affects MIA40 function. Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P. Cell Death Dis. 2015;6:e1814.
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Calcium signaling then and now, via Stockholm. Bano D, Jewell SA, Nicotera P. Biochem Biophys Res Commun. 2016.
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Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Piazzesi A, Papic D, Bertan F, Salomoni P, Nicotera P, Bano D. Cell Rep. 2016;17(4):987-96.