Dr. Ullrich Wüllner
Professor
Center for Neurodegenerative Diseases
German Centre for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen)
Germany
Biography
Ullrich Wuellner earned his doctorate in 1990 in Göttingen, and then worked until 1992 as a research associate at McLean Hospital at Harvard University, Boston, MA. In 1998, he completed his residency in the field of neurology and psychiatry at the University Hospital of Tübingen. There he received the "venia legendi" and habilitated in 1999. From 1999 to 2001, Ullrich Wuellner worked as senior consultant in neurology at the University Hospital of Bonn, and has been deputy director there since 2001. In addition, as of 2012, he also serves as a group leader at the DZNE Bonn.
Research Interest
His research topics are: molecular and cellular pathogenesis of neurodegenerative disorders, i.e. cerebellar ataxias, polyglutamine disease, Parkinson's disease, Multiple System Atrophy; neurogenetics, epigenetics Molecular imaging Clinical research: Movement disorders, sleep medicine, stroke, pharmacology
Publications
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Methylation of alpha-synuclein regulates expression and is decreased in Parkinson's disease patients’ brains. Jowaed A, Schmitt I, Kaut O, Wüllner U. JNeurosci, 2010 30(18):6355-92010
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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium. Sci Transl Med. 2010;2(52):52ra73
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Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tüting T, Hoffmann P, Klockgether T, Evert BO, Wüllner U, Brüstle O. Nature. 2011;480(7378):543-6.
