Dr. Christoph Cremer
Professor
Director Research Area "Applied Optics & Information Process
Heidelberg University
Germany
Biography
Diploma in Physics (Univ. München); Dr.rer.nat. in Biophysics/Genetics (Univ. Freiburg); Dr.med.habil. for General Human Genetics and Experimental Cytogenetics (Univ. Freiburg); Professor (Ordinarius) University Heidelberg 1983 - 2011 Director "Applied Optics and Information Processing", KIP / Kirchhoff Institute for Physics. Since 2005 Director Biophysics of Genome Structure, Institute for Pharmacy and Molecular Biotechnology (IPMB), University Heidelberg Member Faculty of Physics and Astronomy and (cooptated) Faculty for Biosciences and the Medical Faculty Mannheim Mannheim, University Heidelberg. 2006 - 2009 Second Speaker of the Academic Senate of Heidelberg University. 2003 - 2014 Adjunct Senior Staff Scientist, The Jackson Laboratory, Bar Harbor/ME Since August 1, 2011 Head Lightoptical Nanoscopy/Super-Resolution Microscopy, Institute of Molecular Biophysics, D-55128 Mainz, Germany Since 2013 Honorary Professor (Physics), University Mainz (JGU) Since 2015 Research Associate Max Planck Institute for Chemistry, Mainz emails: cremer@kip.uni-heidelberg.de, cremer@bmm.uni-heidelberg.de, c.cremer@imb-mainz.de
Research Interest
the application of superresolution microscopy methods to analyse membrane complexes, cell to cell interactions, as well as allergenic responses on the nanostructural level.
Publications
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K. Prakash, D. Fournier, S. Redl, G. Best, M. Borsos, R. Ketting, K. Tachibana-Konwalski, C. Cremer, U. Birk (2015) Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes, Proc. Natl. Acad. Sci. USA 112 (47):14635–14640.
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I.Kirmes, A. Szczurek, K. Prakash, I. Charapits a,, C. Heiser, M. Musheev, F. Schock, K. Fornalczyk, D. Ma, U. Birk, C. Cremer, G. Reid (2015) A transient ischemic environment induces reversible compaction of chromatin. Genome Biology 16: 246 (pp. 1-19), doi: 10.1186/s13059-015-0802-2.
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Grab AL, Hagmann M, Dahint R, Cremer C (2015). Localization microscopy (SPDM) facilitates high precision control of lithographically produced nanostructures. Micron 68: 1–7.
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U. Birk, C. Cremer (2016) Perspectives in Super Resolved Fluorescence Microscopy:What Comes Next? Frontiers in Physics 4: Article11. doi: 10.3389/fphy.2016.00011.
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R. Lopez Perez,G. Best,N. H. Nicolay,C. Greubel, S.Rossberger,J. Reindl, G. Dollinger, K.-J. Weber, C. Cremer, P. E. Huber (2016) Superresolution light microscopy shows nanostructure of carbon ion radiation-induced DNA double-strand break repair foci. The FASEB Journal 30:2767-2776.
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A.Szczurek, L. Klewes, J. Xing, A. Gourram, U. Birk, H. Knecht, J. W. Dobrucki, S. Mai, C. Cremer (2017) Imaging chromatin nanostructure with binding-activated localisation microscopy based on DNA structure fluctuations. Nucleic Acids Research 2017, 1–11.doi: 10.1093/nar/gkw1301.
