Karin Von Schwarzenberg
CHEMISTRY
Institut Pasteur de Bangui
Germany
Biography
University of Munich Department of Pharmacy - Center for Drug Research Pharmaceutical Biology Butenandtstr. 5-13 81377 Munich, Archazolid is a myxobacterial compound inhibiting the function of the v-ATPase, a proton pump responsible for pH regulation throughout most eukaryotic cells. It is found to be overexpressed in a variety of tumor cells correlating with the treatment resistance of these cells. The aim of this project is to analyze the mechanisms leading to archazolid-induced apoptosis and growth inhibition of highly metastatic tumor cells and to characterize the role of v-ATPase in these processes.
Research Interest
Archazolid is a myxobacterial compound inhibiting the function of the v-ATPase, a proton pump responsible for pH regulation throughout most eukaryotic cells. It is found to be overexpressed in a variety of tumor cells correlating with the treatment resistance of these cells. The aim of this project is to analyze the mechanisms leading to archazolid-induced apoptosis and growth inhibition of highly metastatic tumor cells and to characterize the role of v-ATPase in these processes.
Publications
-
V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.
-
MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.
