John Hanley
Network of European Neuroscience Institutes
Network of European Neuroscience Institutes (ENI-NET)
Germany
Biography
Professor John HanleySchool of Biochemistry – Neuroscience at Bristol
Research Interest
The overarching aim of my research is to investigate molecular mechanisms that underlie brain function, in particular synaptic transmission. A primary focus of the lab is the regulation of AMPA receptor trafficking, in particular how the actin cytoskeleton controls this process during synaptic plasticity. We are particularly interested in the protein PICK1, which links membrane proteins to Arp2/3-mediated actin polymerisation to regulate trafficking. In addition, we study how actin dynamics regulate dendritic spine morphology during plasticity. Research in the lab uses biochemical, molecular and imaging techniques.
