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Bernhard Nieswandt

Chair of Experimental Biomedicine
Chair of Experimental Biomedicine - Vascular Medicine Rudolf
The Julius Maximilian University of Wurzburg
Germany

Biography

Education and Training 1989 – 1992 Undergraduate student of Biology at the University of Regensburg, Germany 1992 – 1993 Undergraduate student of Biochemistry at the University of Kent, UK 1993 University Diploma in Biochemistry, University of Kent, UK 1994 University Diploma in Biology, University of Regensburg, Germany 1994 - 1997 PhD student at the Institute of Pathology/Tumorimmunology, University of Regensburg, Germany. 2002 “Habilitation” in Experimental Medicine at the Medical Faculty of Witten/Herdecke University. Positions and Employment 1998 – 2002 Research group leader at the Department of Molecular Oncology, General Surgery, Witten/Herdecke University, Germany 2002 – 2007 Research group leader at the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg (DFG research center for experimental biomedicine), Germany 2002 – 2004 Heisenberg Fellow of the German Research Foundation (DFG) since 03/2007 Research Professor, Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Germany 2004 – 2008 Professor (C3/W2) of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Germany since 12/2008 Chair of Experimental Biomedicine – Vacular Medicine, University Hospital and Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Würzburg, Germany since 04/2011 Coordinator of the Collaborative Research Center (SFB) 688 „Mechanisms and Imaging of Cardiovascular Cell-Cell Interactions“

Research Interest

Main interests Platelet function in thrombosis, hemostasis and inflammatory disease. Platelet biogenesis.  Ongoing research support o Mechanismen des Agonist-induzierten Ca2+-Einstroms in Thrombozyten in vitro und in vivo o Die Rolle von Rho GTPasen in Thrombozytenbildung und -funktion: Studien in konditionalen knock-out Mausmodellen o Mechanismen der Ca2+-Regulation in Thrombozyten o Die Bedeutung von Mg2+ Kanälen für Thrombose und Hämostase o Untersuchungen zur zellulären Regulation thrombozytärer Adhäsionsrezeptoren in Hämostase und Thrombose o Zell-Zell-Interaktion in der Pathogenese des Hirninfarktes: Mechanismen der Thrombenbildung und MR-Bildgebung

Publications

  • Thrombopoiesis is spatially regulated by the bone marrow vasculature. Twinfilin 2a is a regulator of platelet reactivity and turnover in mice. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Platelet receptors as therapeutic targets: Past, present and future. Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke.

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