Philipp Zuber
Chemistry
University of Bayreuth
Germany
Biography
Philipp Zuber is Researcher from Department of Chemistry in University of the Basque Country. Zuber is profound in Molecular Biology
Research Interest
Transcription as a first step in gene expression is central to all organisms. Over time, bacterial transcription has become established as a model system because of its relative simplicity and good experimental accessibility. The main players in transcription are the DNA-dependent RNA polymerases (RNAPs), which are regulated by numerous transcription factors. An important, and at the same time the only conserved, class of transcription factors is the family of NusG / Spt5 proteins. These play important, often essential roles during the elongation or termination phase of transcription. However, the underlying molecular mechanisms are not fully understood. During my PhD thesis, I would like to focus on the regulation of bacterial transcription by NusG proteins. This includes, above all, the elucidation of structure-function relationships as well as the investigation of protein: protein or protein: nucleic acid interactionsin vitro .
