Prof. Dr. Frank M. Böckler
Professor
Pharmaceutical Chemistry
University of Tubingen
Germany
Biography
Prof/Dr.Frank M. Boeckler received his Ph.D. in Medicinal Chemistry at the University of Erlangen (Germany) in 2004 under supervision of Prof. Peter Gmeiner. He specialized in computational chemistry and drug design, ranging from QM methods to in silicoscreening. He now heads the Laboratory for Molecular Design & Pharmaceutical Biophysics. His work is dedicated to understanding molecular interactions as the foundation for chemical biology and drug research and to apply theoretical and biophysical methods to cancer research, particularly,for targeting the extensive p53 network.
Research Interest
chemical biology and drug research , theoretical and biophysical methods to cancer research
Publications
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Lange A, Günther M, Büttner FM, Zimmermann MO, Heidrich J, Hennig S, Zahn S, Schall C, Sievers-Engler A, Ansideri F, Koch P. Targeting the gatekeeper MET146 of C-Jun N-Terminal Kinase 3 induces a bivalent halogen/chalcogen bond. Journal of the American Chemical Society. 2015 Nov 12;137(46):14640-52.
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Joerger AC, Bauer MR, Wilcken R, Baud MG, Harbrecht H, Exner TE, Boeckler FM, Spencer J, Fersht AR. Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53. Structure. 2015 Dec 1;23(12):2246-55.
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Zimmermann MO, Boeckler FM. Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and π⋯ π interactions using N-methylacetamide. MedChemComm. 2016;7(3):500-5.
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Ansideri F, Lange A, El-Gokha A, Boeckler FM, Koch P. Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase. Analytical biochemistry. 2016 Jun 15;503:28-40.
