Patrick Kobina Arthur
Lecturer
Department of Biochemistry, Cell and Molecular Biology
University of Ghana
Ghana
Biography
Patrick Kobina Arthur is currently working as a Lecturer in Department of Biochemistry, Cell and Molecular Biology, University of Ghana.
Research Interest
Isolation and characterization of novel bioactive compounds from organisms originating from tropical-equatorial biodiversity hotspots, namely: Basidiomycetes (Wood Decaying Fungi), Ascomycetes (Marine Endophytic Fungi) Microalgae Actinomycetes Targeted Proteomics (Selected Reaction Monitoring) of Mycobacteria (in collaboration with the Aebersold Lab, ETH-Zurich, Switzerland). Chemical proteomics of target proteins in human parasites to specific novel bioactives and vice versa as well as corresponding off-target cellular proteins in humans Comparative and functional proteomics on target proteins & specific novel bioactives Clinical proteomics of novel bioactives, identification of biomarkers for in vivo activities Protein Biochemistry - Establish a library of 100 enzymes for molecular biology applications Molecular and structural dynamics of ribonucleoprotein complexes.
Publications
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Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma. Koebernick K, Loeber J, Arthur PK, Tarbashevich K, Pieler T. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16148-53.
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Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway. Arthur PK, Alvarado LJ, Dayie TK., Protein Expr Purif. 2010 Nov 23.
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Schubert, O. T., Mouritsen, J., Ludwig, C., Rost, H. L., Rosenberger, G., Arthur, P. K., Claassen, M., Campbell, D. S., Sun, Z., Farrah, T., Gengenbacher, M., Kaufmann, S.H.E., Moritz, R. L., Aebersold, R. (2013) 'The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of Mycobacterium tuberculosis', Cell Host Microbe 13(5): 602-12
