Zervou Maria
Researcher
Institute of Biology, Medicinal Chemistry and Biotechnology
Athens
Greece
Biography
2002: Ph.D. Chemistry, University of Patras 1992: M.Sc. Electronic Engineering, Department of Physics, University of Athens 1989: B.Sc. Physics, University of Athens Appointments 2013-present: Researcher B' at the Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens 2006-2013: Researcher C' at the Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 2003-2006: Special Functional Scientist at the Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 1992-2003: Special Technical Scientist at the Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens
Research Interest
Research Interests  Drug design by applying NMR spectroscopy and in silico studies. Synergistic use of Bio-NMR and molecular modeling. Topics: antihypertensive AT1 antagonists, aspatic-protease inhibitors, DHEA neurosteroid analogs, glycogen phosphorylase inhibitors, bioactive peptides. Studies also address new repellents for the malaria-transmitting mosquito A.gambiae.  NMR- and LC-MS based metabolomics. Topics: metabolomics in algae research, applications in high added-value natural products as traditional beverages  Structure elucidation of novel bioactive metabolites of plant or marine origin, structure characterization of metal-ligand complexes and nanostructures.
Publications
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3. C. Fotakis, D. Christodouleas, K. Kokkotou, M. Zervou*, P. Zoumpoulakis, P. Moulos, M. Liouni, A. Calokerinos. NMR metabolite profiling of Greek grape marc spirits. Food Chemistry 2013, 138, 1837–1846
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2. M. Zervou*, Z. Cournia, C. Potamitis, G. Patargias, S. Durdagi, S. Golic Grdadolnik, T. Mavromoustakos. Insights into the Molecular Basis of Action of the AT1 Antagonist Losartan Using a Combined NMR Spectroscopy and Computational Approach. BBA Biomembranes, doi: 10.1016/j.bbamem.2013.12.012, (2013).
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1. M. Mondal, N. Radeva, H. Koster, A. Park, C. Potamitis, M. Zervou, G. Klebe, A. K. H. Hirsch. Structure-Based Design of Novel Inhibitors of the Aspartic Protease Endothiapepsin Exploiting Dynamic Combinatorial Chemistry. Angew Chem Int Ed, Accepted (2014)
