Nullin Divecha

Biography

Nullin Divecha is a Professor of Cellular Signalling within Biological Sciences at the University of Southampton. Career History 2017-Present: Professor in Cellular Signalling. University of Southampton, UK. 2015-2017: Joint Position European Fellow. Institute of molecular genetics (INGM), Milan, Italy. 2014-2017: Associate Professor. Biological Sciences, University of Southampton, UK. 2007-2013: Senior PI, The Manchester Cancer Institute, Manchester, UK. 1997-2007: Senior PI, The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands. 1993-1997: Junior Group Leader. The Babraham Institute, Cambridge, UK. 1988-2003: Postdoctoral Fellow, Prof. R. F. Irvine. The Babraham Institute, Cambridge, UK. 1985-1988: Postgraduate, Dr. Charles McDonald. Biochemistry, Sheffield University, Sheffield, UK. 1982-1985: Undergraduate. Biochemistry, University of Manchester, Manchester, UK. Academic Qualification 1985-1988: Ph.D: the role of proline Rich Proteins. University of Sheffield, UK. 1982-1985: BSc in Biochemistry. University of Manchester, UK.

Research Interest

Inflammation, diabetes and many other diseases can be considered to be the result of deregulated signalling pathways that normally enable the cell to properly respond to environmental changes. Phosphoinositides are a family of seven lipid messengers that are present in many subcellullar compartments (figure 1 ). Specific subcellullar phosphoinositide profiles are controlled by kinases, phosphatases and phospholipases which respond to both extracellular and intracellular cues. In this manner phosphoinositides transduce environmental stimuli into downstream cellular responses. Amongst other mechanisms phosphoinositides transduce signals by interacting with proteins to change the proteins intracellular location or function (figure 2).