Leonidas Stefanis
Affiliated Investigator
Molecular Biology
BRFAA
Greece
Biography
Dr. Stefanis obtained his MD from the University of Athens Medical School in 1987. He subsequently obtained his PhD from the same University in 1992, with work related to the molecular basis of thalassemia. Dr. Stefanis is investigating various areas of PD pathogenesis, ranging from the bench to the bedside. He is examining the genetic underpinnings of the disease in the Greek population, not only in the rare familial, but also in sporadic cases.
Research Interest
His research interest lie in to examine the utility of using alpha-synuclein as a disease biomarker.
Publications
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Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L (2013) Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration. Brain 136:2130-46
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Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L (2012) Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. Hum Mol Genet. 21(4):874-89
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Bozi M, Papadimitriou D, Antonellou R, Moraitou M, Maniati M, Vassilatis DK, Papageorgiou SG, Leonardos A, Tagaris G, Malamis G, Theofilopoulos D, Kamakari S, Stamboulis E, Hadjigeorgiou GM, Athanassiadou A, Michelakakis H, Papadimitriou A, Gasser T, Stefanis L (2014) Genetic assessment of familial and early-onset Parkinson's disease in a Greek population. Eur J Neurol. [Epub ahead of print]
