Dr. Christoph Müller
Head of Unit and Senior Scientist
sequence-specific transcription factors assemble on DNA and
EMBLEM Technology
Greece
Biography
Biography PhD 1991, University of Freiburg. Postdoctoral work at Harvard University, Cambridge, USA. Group leader at EMBL Grenoble since 1995. Head of Unit at EMBL Heidelberg since 2007. Joint appointment with the Genome Biology Unit. ERC Advanced Investigator.
Research Interest
Previous and current research We study how sequence-specific transcription factors assemble on DNA and how they interact with co-activators and general transcription factors to recruit RNA polymerases to their transcription start sites. We are also interested in the overall structure, architecture and the inner workings of large molecular machines involved in the transcription process, such as RNA polymerases I and III, their specific pre-initiation complexes and chromatin modifying complexes. Finally, we would like to gain insight into how DNA sequence information and epigenetic modifications work together to regulate gene transcription. To achieve these goals, we use structural information obtained by X-ray crystallography and cryo-electron microscopy combined with other biophysical and biochemical approaches.
