George A. Garinis
Genetics
IMBB Group
Greece
Biography
He Research in our laboratory is focused on: a. The impact of genome instability on pathways associated with longevity, aging and age-related pathology: We aim to identify common genome-wide expression patterns between a number of TCR-defective, progeroid mice and mice that carry (tissue-specific) constitutive defects in transcription. We are using a number of advanced molecular, genomics and imaging approaches to investigate the role of transcriptional instability in progeria and age-related pathology. b. The impact of progeroid mutations on tumour development: we aim at investigating the fine balance between cancer protection and accelerated aging. This approach might provide us both with mechanistic insight into the complex process of tumorigenesis as well as gene targets for its experimental modulation in the future. c. Genome instability and tissue-specific progeria: we are focusing at investigating age-related processes driven by genome instability in a tissue-specific manner using the loxP/ Cre recombinase technology to restrict DNA repair deficiency in a single type of tissue while leaving the remaining part of the organism intact. d. Development of advanced bioinformatics approaches to integrate functional genomics data with and biological endpoints in cancer and aging.
Research Interest
genomics data with and biological endpoints in cancer and aging.
