John E. Coligan
Chief
Receptor Cell Biology
NIAID-laboratory of Immunogenetics
Greece
Biography
Dr. Coligan received his Ph.D. from Indiana University and did postdoctoral research at the City of Hope Research Institute. After two years as an assistant professor at Rockefeller University, he was a founding member of the Laboratory of Immunogenetics. He has served as head of the Biological Resources Branch and Laboratory of Molecular Structure. In 1998, he joined the Laboratory of Allergic Diseases and became chief of the Receptor Cell Biology Section (RCBS). In 2007, this section moved to the Laboratory of Immunogenetics. His current research is focused on regulation of the immune response by CD300 family receptors and elucidating the mechanism of lytic granule exocytosis in NK cells.
Research Interest
Role of CD300 family receptors in regulating the immune response, focusing on autoimmunity, inflammatory bowel disease, septic shock, and cancer Role of granule/lysosomal proteins in regulating natural killer (NK) cell cytolytic activity in relation to the molecular mechanisms underlying defective NK cell cytotoxicity in rare immunodeficiency diseases like Hermansky-Pudlak syndrome
