Tomasz Proszynski
Cell Biology
The Nencki Institute at Warsaw
Greece
Biography
The precise remodeling is critical for the functioning of synapses in the central nervous system (CNS) and the peripheral nervous system (PNS). Thus, synaptic malleability is in the center of attention of neurobiological research. Because of its simplicity, size and accessibility, the neuromuscular junction (NMJ) serves as a useful model to study the biology of synapses. Like synapses in the CNS, NMJs undergo postnatal developmental changes in which simple assemblies rearrange into morphologically complex structures. Abnormalities in NMJs’ development have been observed in numerous disorders, including congenital myasthenic syndromes. However, the machinery responsible for the remodeling of these synapses is widely unknown. We use multidisciplinary approaches to elucidate mechanisms that orchestrate the maturation of NMJs during postnatal development.
Research Interest
Cell Biology/Synaptogenesis
