Christophe Mulle
Neuroscience
The Neuroscience Institute at Bordeaux
Greece
Biography
Christophe Mulle studied at the Ecole Normale Supérieure in Cachan. He is a cellular neurobiologist expert in electrophysiology of synaptic transmission and glutamate receptors. After a PhD at the Pasteur Institute with Jean-Pierre Changeux and a post-doc at the Salk Institute with Steve Heinemann, he has been guiding a CNRS laboratory in Bordeaux since 1995. His research ambitions to link cell biological mechanisms of protein trafficking to synaptic physiology and to address synaptic dysfunction in models of cognitive disorders such as Alzheimer's disease. He has contributed to the understanding of the elusive kainate receptors as regulators of neural circuits and provided the first insights into the molecular events that govern their polarized trafficking. In recent years he has investigated the mechanisms of synaptic integration and plasticity in hippocampal CA3 pyramidal cells. A unique strength of his team is its ability to implement interdisciplinary studies, bridging molecular and cellular techniques to physiological questions in vitro, and in vivo in the context of episodic memory encoding.
Research Interest
Cellular Biology of glutamatergic synaptic transmission
