Rgiris Efstratiadis

Biography

Dr. Argiris Efstratiadis is a scientist who fights against breast cancer as his laboratory is focused on mouse developmental genetics, with emphasis on the role of growth factors in normal development and malignancy, specifically mammary tumour progression, including research on the murine homologs of the breast cancer susceptibility genes Brca1 and Brca2, and the involvement of the Notch signaling pathway in breast tumours. Except of breast tumours, his additional work on tumorigenesis includes the development of novel approaches for modelling cancer at anatomical sites of choice (“designer tumours”), preclinical studies to treat breast cancer in mice with drugs inhibiting IGF signaling (picropophyllin derivatives), studies on the involvement of stem cells in tumour initation, and development of mouse models for prostate and pancreatic cancer.

Research Interest

Growth, considered as an increase in size until a limit is attained, is a fundamental developmental process.