Chan Chung Ngor Juliana
Medicine and Therapeutics
Li Ka Shing Institute of Health Sciences
Professor Juliana Chan is a clinician scientist who graduated from The Liverpool University, UK with accreditations in endocrinology and clinical pharmacology. Since joining The CUHK in 1989, she has built up a 60-member multidisciplinary team to discover, disseminate and apply knowledge in the field of diabetes and its co-morbidities in Chinese populations. Based on the Hong Kong Diabetes Registry established since 1995, accompanied by a biobank, her team has validated a series of risk equations and discovered a panel of genetic variants predictive of diabetes and its complications in Chinese populations with patents awarded by US-FDA and China SFDA. Her team is now using a multidisciplinary, multiomic, multimethod approach to study the missing heritability of young-onset diabetes and biological significance of novel loci on beta cell and developmental biology. To further address the unmet needs in diabetes, her team has received major grants to study the mechanisms and clinical effectiveness of Chinese Medicine in diabetes and obesity using state of the art methodology. Inspired by the marked benefits of team-based protocol-driven care in clinical trial setting, she has integrated the components of risk stratification and empowerment into a web-based disease Joint Asia Diabetes Evaluation (JADE) Program to translate evidence to practice and evaluate cost-effectiveness of interventions in real settings in Asia. She has supervised 50 postgraduate students and scientists and co-authored in over 330 peer reviewed articles and 20 book chapters. She is a member of the NIH-funded Global Consortium to discover diabetes genes, steering committees of multicentre outcome trials, and advisory boards for government and organisations including the World Health Organization and the International Diabetes Federation (IDF), a global advocacy body for people with diabetes. Over the years, her team has set up a CUHK-affiliated multidisciplinary diabetes centre, a community-based nurse-led risk assessment centre and a charitable foundation to translate these discoveries into products/services to benefit the community. In 2011, she received the China Women Physicians Association Intercontinental Innovative Award under the Chinese Ministry of Science and Technology. In 2011, the CUHK-PWH Diabetes and Endocrine Centre was selected as one of the 8 IDF Centres of Education for its excellence in professional education and innovative care models.
Epidemiology, genetics, clinical trials and care models
Fan, R., Li, X., Gu, X., Chan, J. C., & Xu, G. (2010). Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis. Diabetes, Obesity and Metabolism, 12(9), 815-824.