Alex Pw Lee
Assistant Professor
Medicine & Therapeutics
The Chinese University of Hong Kong
Hong Kong
Biography
Prof Lee is an academic cardiologist and physician-scientist. He specialises in cardiac imaging with particular interest in echocardiography. His main research interests are heart valve disease, heart failure, advanced techniques in echocardiography (3D, strain, and contrast), and the application of cardiac imaging in guiding valvular surgery and structural heart intervention. He is particularly keen in collaborating with engineers to innovate diagnostic and therapeutic strategies for cardiovascular disease. In patients with dilated cardiomyopathy undergoing mitral valve repair, he established the importance of distal anterior leaflet tethering in the mechanism of recurrence of functional mitral regurgitation. Based on his work, the echocardiographic parameter of distal anterior leaflet angle has been officially incorporated into the position statement from the European Society of Cardiology and the recommendations from the American Society of Echocardiography on cardiovascular surgery and valvular heart disease.
Research Interest
Cardiac imaging, advanced echocardiography techniques, biomedical engineering, heart valve disease, structural heart intervention, heart failure
Publications
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Lee AP, Song JK, Yip GW, Zhang Q, Zhu TG, Li C, Chan A, Yu CM. Importance of dynamic dyssynchrony in the occurrence of hypertensive heart failure with normal ejection fraction. Eur Heart J. 2010;31:2642-9.
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Lee AP, Acker M, Kubo SH, Bolling SF, Park SW, Bruce CJ, Oh JK. Mechanisms of recurrent functional mitral regurgitation after mitral valve repair in nonischemic dilated cardiomyopathy: Importance of distal anterior leaflet tethering. Circulation. 2009;119:2606-14.
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Lee AP, Hsiung MC, Salgo IS, Fang F, Xie JM, Zhang YC, Lin QS, Looi JL, Wan S, Wong RH, Underwood MJ, Sun JP, Yin WH, Wei J, Tsai SK, Yu CM. Quantitative analysis of mitral valve morphology in mitral valve prolapse using real-time three-dimensional echocardiography: Importance of annular saddle-shape in pathogenesis of mitral regurgitation. Circulation 2013;127:832-41.
