Andy C K Siu
University of Hong Kong
Chi-Kit Andy Siu received his B.Sc. degree (1997) and M.Phil. (1999) and Ph.D. (2003) degrees from the Chinese University of Hong Kong under the supervision of Zhifeng Liu. He won an Alexander von Humboldt Fellowship in 2003 and worked as a postdoctoral fellow in the research group of Vladimir E. Bondybey at the Technical University of Munich (2003 - 2005). In 2005 - 2009, he worked as a postdoctoral fellow in the research groups of K. W. Michael Siu and Alan C. Hopkinson at York University. He joined the City University of Hong Kong in November 2009.
Proteomics allow the large-scale identification of proteins in complex biological systems, but it often only produces static snapshots of proteomes that fail to describe and explain the dynamic nature of cellular behaviours. In contrast, modern cell imaging techniques allow the quantitative analysis of the spatial and temporal distribution of biomolecules in living cells, but only a relatively small number of proteins can be studied in one experiment. Our lab strives to bring together these two powerful methodologies to tackle fundamental biological questions. To this end, we perform quantitative mass spectrometry to measure the flux of a large number of proteins through subcellular spaces and to track the proteomic changes within cellular complexes through time. In parallel, we record these dynamic cellular behaviours in live cells using time-lapse fluorescence microscopy. From these two angles, we aim at building coherent pictures of intracellular events under different growth and metabolic conditions. This lab aims to apply this dual approach to a range of topics, from basic cell biology to environmental sciences