Csaba SÅ‘ti

Biography

Csaba SÅ‘ti is working as a professor at Semmelweis University

Research Interest

The research area of the ER redox lab at the Department of Medical Chemistry, Molecular Biology and Pathobiochemistry is the study of the redox homeostasis of the endoplasmic reticulum. The MEDinPROT project (“The role of regulatory proteins in ageing processes”) focuses on the functional links between the proteins regulating mobile genetic elements, (Vellai’s team), autophagy and ER stress response (Bánhegyi’s team) and the thermal shock protein systems. While monitoring the activity of certain age dependent elements of autophagy, ER stress and thermal shock systems, a reduction can be observed while advancing in age. We presume that the gradually increasing activities of the mobile genetic elements in the somatic genome (taking into consideration that almost half of the human genome is made up of such mobile genetic elements) are responsible for the ageing process through transposone mutagenesis.