József Mandl

Biography

József Mandl is working as a professor at Semmelweis University

Research Interest

The rate of mitochondrial DNA (mtDNA) mutations significantly increases with age progression that may lead to mitochondrial dysfunctions. Based on the mitochondrial cascade hypothesis, the individual’s genetic background determines the mitochondrial function and its durability. This determines the rate of the individual’s age dependent mitochondrial decline. When the mitochondrial function drops below a certain limit, several defects typical of old age appear. In the study of ageing cytoplasmatic hybrid cell lineages with mtDNA mutations must be created. With the help of the cell lineages we aim to study the process of oxidative protein folding. The final acceptor of the oxidative protein folding is the mitochondrial electron transfer chain, thus it may work with a reduced efficiency in old age/in case of mtDNA defect. Ageing is accompanied by mitochondrial functional change, which may affect drug biotransformation or the biotransformation of drug molecules may interfere with the ER and mitochondrial redox conditions. Therefore, we aim to study the impact of these processes exerted on each other on the cybrid lineages that we have created.